Journal Artical Staphloccocus

Journal : Article Critique Article ReviewTitle of the ArticleKennedy , AD , Otto , M , Braughton , KR , Whitney , AR , Chen , L , Mathema B , Mediavilla , JR , Byrne , KA , Parkins , LD , Tenover , FC , Kreiswirth BN , Musser , JM , and DeLeo , FR (2008 . Epidemic community-associated methicillin-resistant Staphylococcus aureus : Recent clonal expansion and diversification . PNAS vol . 105 , no . 4 , 1327-1332BackgroundCommunity-associated methicillin resistant Staphylococcus aureus is a major health problem , leading to epidemic relation of the affection extremely difficult to control . This epidemic in the USA has been termed to be caused by a classified do work of the bacteria named USA300 . It has been suggested that clonal expansion and diversification of the bacterial drag whitethorn be responsible for hypervirulence o f a specific phenotype .

Although the evolutionary and molecular underpinnings of the epidemic are not understood all in all , a clear understanding of the phylogeny of this strain may be helpful to understand the virulence and the propensity of future(a) disease burden betterHypothesisClonal emergence of USA 300 isolates or evolutionary convergence towards a hypervirulent phenotype may result in self-directed appearance of similar organisms leading to temporal change in disease frequency . To elucidate this hypothesis finished geographical expedition of molecular and genetic diversity of the strain causation such epidemics , a whole genome sequencing of the isolates may prove to b e usefulMethodologyAnalysis of 11 USA300 pat! ient isolates of S . aureus from eight states in versatile geographic regions in the United States from multiple types of human infections was conducted with PGFE . Comparative genome sequencing of these isolates by...If you indirect request to get a full essay, regularise it on our website: OrderEssay.net

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